The C4 to T2 spinal nerves contributes to the anterior (ventral) rami of lower four cervical and the first thoracic (i.e., C5, C6, C7, C8, and T1) spinal nerves in order to form the brachial plexus which is the plexus of nerves.
The prefixed brachial plexus is formed largely by the contribution from C4 and in the absence of T2. On the other hand, postfixed brachial plexus is formed largely by the contribution from T2 and in the absence of C4.
INTERACTIVE ANATOMICAL INTERFACE
The brachial plexus consists of four components: (a) roots, (b) trunks, (c) divisions, and (d) cords. The roots and trunks arc located in the neck, divisions behind the clavicle and the cords in the axilla.
The roots of the brachial plexus are the anterior rami of C5 to C8, and most of Tl. Close to their origin, the roots receive gray rami communicantes from the sympathetic trunk. These carry postganglionic sympathetic fibers onto the roots for distribution to the periphery. The roots and trunks enter the posterior triangle of the neck by passing between the anterior scalene and middle scalene muscles and lie superior and posterior to the subclavian artery.
The three trunks of the brachial plexus originate from the roots, pass laterally over rib I, and enter the axilla:
- The superior trunk is formed by the union of C5 and C6 roots.
- The middle trunk is a continuation of the C7 root.
- The inferior trunk is formed by the union of the C8 and T1 roots.
The inferior trunk lies on rib I posterior to the subclavian artery; the middle and superior trunks are more superior in position.
Each of the three trunks of the brachial plexus divides into an anterior and a posterior division:
- The three anterior divisions form parts of the brachial plexus that ultimately give rise to peripheral nervesassociated with the anterior compartments of the arm and forearm.
- The three posterior divisions combine to form parts of the brachial plexus that give rise to nerves associated with the posterior compartments.
- No peripheral nerves originate directly from the divisions of the brachial plexus.
The three cords of the brachial plexus originate from the divisions and are related to the second part of the axillary artery:
- The lateral cord results from the union of the anterior divisions of the upper and middle trunks and therefore has contributions from C5 to C7—it is positioned lateral to the second part of the axillary artery.
- The medial cord is medial to the second part of the axillary artery and is the continuation of the anterior division of the inferior trunk—it contains contributions from C8 and Tl.
- The posterior cord occurs posterior to the second part of the axillary artery and originates as the union of all three posterior divisions—it contains contributions from all roots of the brachial plexus (C5 to T1).
Most of the major peripheral nerves of the upper limb originate from the cords of the brachial plexus. Generally, nerves associated with the anterior compartments of the upper limb arise from the medial and lateral cords and nerves associated with the posterior compartments originate from the posterior cord.
Branches Of The Roots
In addition to small segmental branches from C5 to C8 to muscles of the neck and a contribution of C5 to the phrenic nerve, the roots of the brachial plexus give rise to the dorsal scapular and long thoracic nerves.
The Dorsal Scapular Nerve
- originates from the C5 root of the brachial plexus,
- passes posteriorly, often piercing the middle scalene muscle in the neck,
- to reach and travel along the medial border of the scapula
- and innervates the rhomboid major and minor muscles from their deep surfaces.
The Long Thoracic Nerve
- originates from the anterior rami of C5 to C7,
- passes vertically down the neck, through the axillary
- inlet, and down the medial wall of the axilla to supply
- the serratus anterior muscle, and
- lies on the superficial aspect of the serratus anterior muscle.
Branches of the Trunks
The only branches from the trunks of the brachial plexus are two nerves that originate from the superior trunk (upper trunk): the suprascapular nerve and the nerve to the subclavius muscle.
The suprascapular nerve (C5 and C6):
- originates from the superior trunk of the brachial plexus,
- passes laterally through the posterior triangle of the neck and through the suprascapular foramen to enter the posterior scapular region,
- innervates the supraspinatus and infraspinatus muscles, and
- is accompanied in the lateral parts of the neck and in the posterior scapular region by the suprascapular artery.
The nerve to the subclavius muscle (C5 and C6) is a small nerve that:
- originates from the superior trunk of the brachial plexus,
- passes anteroinferiorly over the subclavian artery and vein, and
- innervates the subclavius muscle.
Branches of the Lateral Cord
Three nerves originate entirely or partly from the lateralcord.
- The lateral pectoral nerve is the most proximal of the branches from the lateral cord. It passes anteriorly, together with the thoraco-acromial artery, to penetrate the clavipectoral fascia that spans the gap between the subclavius and pectoralis minor muscles, and innervates the pectoralis major muscle.
- The musculocutaneous nerve is a large terminal branch of the lateral cord. It passes laterally to penetrate the coracobrachialis muscle and pass between the biceps brachii and brachialis muscles in the arm, and innervates all three flexor muscles in the anterior compartment of the arm, terminating as the lateral cutaneous nerve of the forearm.The lateral root of the median nerve is the largest terminal branch of the lateral cord and passes medially to join a similar branch from the medial cord to form the median nerve.
Branches of the Medial Cord
The medial cord has five branches.
- The medial pectoral nerve is the most proximal branch. It receives a communicating branch from the lateral pectoral nerve and then passes anteriorly between the axillary artery and axillary vein. Branches of the nerve penetrate and supply the pectoralis minor muscle. Some of these branches pass through themuscle to reach and supply the pectoralis major muscle. Other branches occasionally pass around the inferior or lateral margin of the pectoralis minor muscle to reach the pectoralis major muscle.
- The medial cutaneous nerve of the arm (medial brachial cutaneous nerve) passes through the axilla and into the arm where it penetrates deep fascia and supplies skin over the medial side of the distal third of the arm. In the axilla, the nerve communicates with the intercostobrachial nerve of T2. Fibers of the medial cutaneous nerve of the arm innervate the upper part of the medial surface of the arm and floor of the axilla.
- The medial cutaneous nerve of the forearm (medial antebrachial cutaneous nerve) originates just distal to the origin of the medial cutaneous nerve of the arm. It passes out of the axilla and into the arm where it gives off a branch to the skin over the biceps brachii muscle, and then continues down the arm to penetrate the deep fascia with the basilic vein, continuing interiorly to supply the skin over the anterior surface of the forearm. It innervates skin over the medial surface of the forearm down to the wrist.
- The medial root of the median nerve passes laterally to join with a similar root from the lateral cord to form the median nerve anterior to the third part of the axillary artery.
- The ulnar nerve is a large terminal branch of the medial cord. However, near its origin, it often receives a communicating branch from the lateral root of the median nerveoriginating from the lateral cord and carrying fibers from C7. The ulnar nerve passes through the arm and forearm into the hand where it innervates all intrinsic muscles of the hand (except for the three thenar muscles and the two lateral lumbrical muscles). On passing through the forearm, branches of the ulnar nerve innervate the flexor carpi ulnaris muscle and the medial half of the flexor digitorum profundus muscle. The ulnar nerve innervates skin over the palmar surface of the little finger, medial half of the ring finger, and associated palm and wrist, and the skin over the dorsal surface of the medial part of the hand.
The median nerve is formed anterior to the third part of the axillary artery by the union of lateral and medial roots originating from the lateral and medial cords of the brachial plexus. It passes into the arm anterior to the brachial artery and through the arm into the forearm, where branches innervate most of the muscles in the anterior compartment of the forearm (except for the flexor carpi ulnaris muscle and the medial half of the flexor digitorum profundus muscle, which are innervated by the ulnar nerve).
The median nerve continues into the hand to innervate:
- the three thenar muscles associated with the thumb,
- the two lateral lumbrical muscles associated with movement of the index and middle fingers, and
- the skin over the palmar surface of the lateral three and one-half digits and over the lateral side of the palm and middle of the wrist.
The musculocutaneous nerve, the lateral root of the median nerve, the median nerve, the medial root of the median nerve, and the ulnar nerve form an M over the third part of the axillary artery. This feature, together with penetration of the coracobrachialis muscle by the musculocutaneous nerve, can be used to identify components of the brachial plexus in the axilla.
Branches of the Posterior Cord
Five nerves originate from the posterior cord of the brachial plexus:
- the superior subscapular nerve,
- the thoracodorsal nerve,
- the inferior subscapular nerve,
- the axillary nerve, and
- the radial nerve.
All these nerves except the radial nerve innervate muscles associated with the posterior wall of the axilla; the radial nerve passes into the arm and forearm.
- The superior subscapular, thoracodorsal, and inferior subscapular nerves originate sequentially from the posterior cord and pass directly into muscles associated with the posterior axillary wall. The superior subscapular nerve is short and passes into and supplies the sub- scapularis muscle.
- The thoracodorsal nerve is the longest of these three nerves and passes vertically along the posterior axillary wall. It penetrates and innervates the latissimus dorsi muscle.
- The inferior subscapular nerve also passes inferiorly along the posterior axillary wall and innervates the subscapularis and teres major muscles.
- The axillary nerve originates from the posterior cord and passes inferiorly and laterally along the posterior wall to exit the axilla through the quadrangular space. It passes posteriorly around the surgical neck of the humerus and innervates both the deltoid and teres minor muscles.
- A superior lateral cutaneous nerve of the arm originates from the axillary nerve after passing through the quadrangular space and loops around the posterior margin of the deltoid muscle to innervate skin in that region. The axillary nerve is accompanied by the posterior circumflex humeral artery.
- The radial nerve is the largest terminal branch of the posterior cord. It passes out of the axilla and into the posterior compartment of the arm by passing through the triangular interval between the inferior border of the teres major muscle, the long head of the triceps brachii muscle, and the shaft of the humerus. It is accompanied through the triangular interval by the profunda brachii artery, which originates from the brachial artery in the anterior compartment of the arm. The radial nerve and its branches innervate all muscles in the posterior compartments of the arm and forearm, and the skin on the posterior aspect of the arm and forearm, the lower lateral surface of the arm, and the dorsal lateral surface of the hand.
- The posterior cutaneous nerve of the arm (posterior brachial cutaneous nerve) originates from the radial nerve in the axilla and innervates skin on the posterior surface of the arm.
Spinal Segment, Nerves And Distribution Table
|c4-c6||Nerve to subclavius||Subclavius muscle|
|C5||Dorsal scapular nerve||Rhomboid and levator scapulae muscles|
|C5-C7||Long thoracic nerve||Serratus anterior muscle|
|C5,C6||Suprascapular nerve||Supraspinatus and infraspinatus muscles; sensory from shoulder joint and scapula|
|C5-T1||Pectoral nerves (medial and lateral)||Pectoralis muscles|
|c5,c6||Subscapular nerves||Subscapularis and teres major muscles|
|Q-C8||Thoracodorsal nerve||Latissimus dorsi muscle|
|c5 – c6||Axillary nerve||Deltoid and teres minor muscles; sensory from skin of shoulder|
|C8,T1||Medial antebrachial cutaneous nerve||Sensory from skin over anterior, medial surface of arm and forearm|
|C5-T1||Radial nerve||Many extensor muscles on the arm and forearm (triceps brachii, anconeus, extensor carpi radialis, extensor carpi ulnaris, and brachioradialis muscles); supinator muscle, digital extensor muscles, and abductor pollicis muscle via the deep branch; sensory from skin over the posterolateral surface of the limb through the posterior brachial cutaneous nerve (arm), posterior antebrachial cutaneous nerve (forearm), and the superficial branch (radial portion of hand)|
|C5-C7||Musculocutaneous nerve||Flexor muscles on the arm (biceps brachii, brachialis, and coracobrachialis muscles); sensory from skin over lateral surface of the forearm through the lateral antebrachial cutaneous nerve|
|C6-T1||Median nerve||Flexor muscles on the forearm (flexor carpi radialis and palmaris longus muscles); pronator quadratus and pronator teres muscles; radial half of flexor digitorum profundus muscle, digital flexors (through the anterior interosseous nerve); sensory from skin over anterolateral surface of the hand|
|C8,T1||Ulnar nerve||Flexor carpi ulnaris muscle, ulnar half of flexor digitorum profundus muscle, adductor pollicis muscle, and small digital muscles through the deep branch; sensory from skin over medial surface of the hand through the superficial branch|
Lesions of the Brachial Plexus
For understanding the effects of the lesions of the brachial plexus, the student will find it helpful to know the spinal segments, which control the various movements of the upper limb:
- Adduction of the shoulder is controlled by C5 segment.
- Abduction of the shoulder is controlled by C6 and C7 segments.
- Flexion of the elbow is controlled by C5 and C6 segments.
- Extension of the elbow is controlled by C6 and C7 segments.
- Flexion of the wrist and fingers is controlled by C8 and T1 segments.
The important lesions of the brachial plexus are as follows:
Erb’s paralysis (upper plexus injury)
It is caused by the excessive increase in the angle between the head and shoulder, which may occur by fall from the back of horse and landing on shoulder or traction of the arm during birth of a child. This involves upper trunk (C5 and C6 roots) and leads to a typical deformity of the limb called policeman’s tip hand/porter’s tip hand/waiter’s tip hand. In this deformity, the arm hangs by the side, adducted and medially rotated, and forearm is extended and pronated. The detailed account of clinical features of Erb’s paralysis is as follows:
- Adduction of arm due to paralysis deltoid muscle.
- Medial rotation of arm due to paralysis supraspinatus, infraspinatus, and teres minor muscles.
- Extension of elbow, due to paralysis of biceps brachii.
- Pronation of forearm due to paralysis of biceps brachii.
- Loss of sensation (minimal) along the outer aspect of arm due to involvement of roots of C6 spinal nerve.
Klumpke’s paralysis (lower plexus injury)
It is caused by the hyperabduction of the arm, which may occur when one falls on an outstretched hand or an arm is pulled into machinery or during delivery (extended arm in a breech presentation. The nerve roots involved in this injury are C8 and T1 and sometimes C7. The clinical features of Klumpke’s paralysis are as follows:
- Claw hand, due to paralysis of the flexors of the wrist and fingers (C6, C7, and C8), and all intrinsic muscles of the hand (C8 and T1).
- Loss of sensations along the medial border of the forearm and hand (T1).
- Horner’s syndrome, (characterized by partial ptosis, miosis, anhydrosis, and enophthalmos) due to involvement of sympathetic fibres supplying head and neck, which leave the spinal cord through T1.
Surgical approach to Axilla
The axilla is approached surgically through the skin of the floor of axilla for the excision of axillary lymph nodes to treat the cancer of the breast. The structures at risk during this procedure are intercostobrachial nerve, long thoracic nerve, thoraco-dorsal nerve, and thoraco-dorsal artery. Effort should be made to safeguard the above structures.